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Effective population size formula in haploid populations undergoing serial bottlenecks

The effective population size is the harmonic mean (time average of $1/N$) of the time dependent population size: $\frac{1}{N_e} = \frac{1}{t_f - t_0} \sum_{t = t_0}^{t_{f}} \frac{1}{N(t)}$ where $t_0$...
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Really having problem comprehending this Hardy-Weinberg example from biology textbook

Here the discussion is highlighting the subtlety between disease 'prevalence' and the 'penetrance' of the mutation causing the disease. The prevalence is an estimated value for the fraction of the ...
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