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I ended up writing directly to Joe after not getting an outside answer here. I won't directly quote him without his permission, but to sum up, he wrote the following: This paper (among others) gives an numerical treatment of different selection coefficients in small populations, which effectively means loci that are not under selection but still have ...


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The definition as set by Kenneth Lange's book is indeed quite vague and thus unrigorous. It is a probability not conditioned on observing an allele $a$ at a locus of $i$ but conditioned on the following where we focus on one particular locus. It is rigorously defined as follows. Then we will give the correct formulation of the correct recursive equation akin ...


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Has interest in haplotype blocks waned over the decade? No. You can set a time range on Google Scholar, which the screenshot shows was not done. I did that and: A search for ‘haplotype block’ from 2000 to 2009 gives 22,000 hits. A search for ‘haplotype block’ from 2000 to 2009 gives 25,700 hits. (The term haploblock is now often used as an abbreviation, ...


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Although I cannot find the Scientific American article to which the poster refers, I assume that the “historic human population size” is the size of the human population in Africa before it underwent the expansion that accompanied the emergence from the African continent. Some important papers on this subject were published in the late 1990s (somewhat later ...


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Let $\theta = 4n\mu$, then $E(S) = \theta\sum\limits_{i=1}^{k-1}\frac{1}{i}$, assuming infinite sites model. This is indeed given by Watterson (1975).


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