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6 votes
Accepted

How valid are GO (Gene Ontology) terms?

There are quite a lot of articles(1,2, etc.) which have investigated this, I think this article did a great job to give a visual representation of the specificity, reliability and coverage: also ...
KingBoomie's user avatar
  • 2,390
6 votes
Accepted

Why is the null hypothesis of trait evolution Brownian motion?

I think that the simple answer to this question is that the present comparative methodology was largely established by Felsenstein 1985, American Naturalist. For mathematical convenience, he suggested ...
Maximilian Press's user avatar
4 votes
Accepted

Pilot agricultural study terminology

There is no one word for it. The design is typically called by its statistical term of "Randomized block design". There's a good study design page that explains all this here from University ...
bob1's user avatar
  • 12.4k
4 votes

How does geography affect morphological features of the human body

Geography does not typically affect the morphology of the human body. In certain special cases, there are physiological adaptations, the most obvious being tanning and acclimatization to high altitude,...
jakebeal's user avatar
  • 6,987
4 votes
Accepted

What are the considerations for studying population genetics of bacterial pan-genomes?

It is possible to perform gene-level population genetics analyses on microbiome-derived bacterial species.1,2 † However, the biology of bacteria and the nature of metagenomic sequencing data make such ...
acvill's user avatar
  • 8,296
3 votes

What are the considerations for studying population genetics of bacterial pan-genomes?

I will answer this as best as I am able, the updates are helpful for providing context. I'll also note that there are several questions packed in here, which makes it a bit more laborious to answer. I ...
Maximilian Press's user avatar
3 votes

Non-coding DNA correlation with rate of evolution

Whether or not species with less non-coding DNA evolve faster, the assumption that this could be explained by their genomes being more susceptible to mutation would seem to me to be based on a false ...
David's user avatar
  • 26.2k
2 votes

What percentage of the fitness variance is explained by the 'n'- most important loci?

This should be taken less as a holistic answer than as a case study describing an extreme example of very strong selection in a particular environmental context, yielding a particular natural ...
Maximilian Press's user avatar
2 votes

How to confirm pure-breeding parents

If they are "pure-breeding", that means that they are homozygous. If they were heterozygous, the offspring would not all have the same color as the parents. But tree-breeding" means they all do.
swbarnes2's user avatar
  • 5,230
2 votes

Learning tensors for evolutionary or developmental biology

The field of tensor decompositons has been discovered in many fields simultaneously, each with their own notation. Many modern notation in fields like CS or STAT have originated from the work of ...
Car Loz's user avatar
  • 121
2 votes

What are the relative frequencies of dominance and codominance in genes underlying phenotypic characters?

It is not clear whether this is an outcome of the real state of affairs, or simply that the additive model is "good enough" for summarizing the complex reality of underlying epistasis, ...
BigMistake's user avatar
2 votes

Why does Falconer's formula for broad sense heritability subtract correlation values instead of r^2 values?

Each of these two estimates (DZ correlation and MZ correlation) express a numerical relationship (Pearson correlation) between individuals. Each of these could independently be squared to provide r^2 ...
Maximilian Press's user avatar
2 votes

How to interpret this statement on missing heritability

Missing heritability refers to the fact that while we make heritability estimates using e.g. midparent regression, we can't actually find gene variants whose effects we can add up to the amount of ...
Maximilian Press's user avatar
1 vote

Why is the null hypothesis of trait evolution Brownian motion?

Just came across a chapter by Felsenstein on phylogenetic inference with quantitative characters. In it, he states this biological justification for using Brownian motion: A quantitative trait that ...
jmah's user avatar
  • 53
1 vote
Accepted

Rigorous definition of the kinship coefficient and proof of a recursion thereof

The definition as set by Kenneth Lange's book is indeed quite vague and thus unrigorous. It is a probability not conditioned on observing an allele $a$ at a locus of $i$ but conditioned on the ...
Hans's user avatar
  • 486
1 vote

RFLP Pedigree question

I said that there isn't enough information to tell since the parents genotypes are unknown. It seems like you are misreading the diagrams since you say the parent's genotypes are unknown. All 8 ...
mgkrebbs's user avatar
  • 9,054
1 vote

Minimum amount of RNA for cDNA conversion and qPCR

Two answers follow: Technical experience of many: it should be no problem to have the same protocol with a twice-lower starting concentration, without making any adjustments whatsoever. The suggested ...
S Pr's user avatar
  • 6,262
1 vote

Does covariance and phenotypic variance have to be for the same trait to calculate narrow-sense heritability?

Does covariance and phenotypic variance have to be for the same trait to calculate narrow-sense heritability? Yes. See below for more information. Can I still calculate the narrow-sense ...
Remi.b's user avatar
  • 68.2k
1 vote
Accepted

Identity by descent among unrelated individuals

The definition of IBD is always the same - an allele or segment of alleles which is shared between two individuals because of descent from a common ancstor. In the context of this paper, the authors ...
user438383's user avatar
  • 2,351

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