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I will keep it very very short and simple. dsRNA is very critical in regulation of gene expression at translational level. In our system we have specific miRNA (micro RNA) that are somewhat complementary to a specific mRNA and miRNA-mRNA binding forms a double stranded molecule that is degraded by our system at a cellular level. So in a way it controls the ...


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N1-methyl-pseudouridine occurs naturally in the tRNAs of most archaea. It replaces the ribothymidine found in the TΨC-loop of eubacterial and eukaryotic tRNAs. Although the enzyme responsible for the conversion of uridine to pseudouridine has been known for some time, it is only relatively recently (2012) that the gene for the methylation of the ...


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