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You cannot use gene expression to estimate fluxes. The reasons are as follows. Gene expression determines mRNA levels which in turn determine enzyme levels. However the relationship between gene expression and enzyme level is not linear. Your biggest problem however is the fluxes are system dependent properties and are not dependent on any single enzyme. A ...


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From Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent: Overall, the cellular and biochemical assays demonstrated a low potential for RDV to elicit off-target toxicity, including mitochondria-specific toxicity, consistent with the reported clinical safety profile. This isn't a very complete answer, but the ...


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