Why do classic psychedelics not cause withdrawal, despite high tolerance?
Short answer Withdrawal effects are generally associated with drugs that induce feelings of euphoria by stimulating the reward center of the brain, either directly (cocaine, morphine) or indirectly (...
Is 5-HTP a SSRI?
No, it isn't considered an SSRI. SSRI stands for selective serotonin re-uptake inhibitor or serotonin-specific reuptake inhibitor, which designates the mechanism by which this category of drug (...
What are the Genes/Enzymes responsible for the supposedly stark between-individual differences in lethargy after eating starches?
The video is likely referencing alpha amylase, which is encoded in humans by AMY1A, a gene that is know to have a high level of inter-individual copy number variation. Some scientists have speculated ...
Why are so many recreational drugs serotonin 5-HT1A partial agonists?
Interesting notion. However, the main effects of the indoleamine-class of psychoactive compounds, including psilocybin and LSD (Shulgin, 1997), are generally ascribed to 5-HT2A receptors and the ...
Do findings on promoter methylation of the serotonin transporter gene and amygdala activity contradict the established view of serotonergic function?
I don't think there is an obvious contradiction here. (1) Mapping neuronal function to the perception of threat (or emotions in general) is often advertised as well-understood, but in fact it is not. ...
Number of serotonergic neurons in mouse/rat DRN
The mouse and rat dorsal raphe nuclei contain about 9000 and about 11.500 serotonergic neurons, respectively. It turns out the corresponding 1988 and 1982 references are widely cited - directly as ...
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