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The monoamine neurotransmitter, serotonin, also referred to by its chemical name 5-hydroxytryptamine (5-HT). It binds to and activates the 5-HT family of receptors.

Serotonin is biosynthesised from the amino acid, tryptophan. It is the precursor compound to the sleep-modulating hormone, melatonin. It binds to, activates and serves as the endogenous ligand for the 5-HT family of receptors which includes:

The 5-HT1 family:

  • 5-HT1A
  • 5-HT1B
  • 5-HT1D
  • 5-HT1E
  • 5-HT1F

The 5-HT2 family:

  • 5-HT2A
  • 5-HT2B
  • 5-HT2C

  • 5-HT3
  • 5-HT4
  • 5-HT5A
  • 5-HT5B
  • 5-HT6
  • 5-HT7

It plays a key role in mood regulation, sleep, anxiety, cognition and sensory perception.

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Figure 1: Serotonin [Source: Chemspider]

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Figure 2: Trytophan [Source: Chemspider]