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Setting up the binomial distribution: For generation F1 each parent (F0) has a 50% chance of contribution the chromosome (under your simplified model), i.e. p=0.5, n=46 for the binomial distribution. I assume that when you say the 'normal' range you are looking for the mean +- 1 standard deviation? For p=0.5, n=46: mean=23 with standard deviation=3.39116 ...


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Please consider this "answer" as an enlarged comment. I can't answer your question, but it's possible that my speculations or considerations could be helpful in your particular situation, in the early phase of building a model. First of all, I doubt that general formulas that link cell-volume to ER-volume of different cell-types can exist. ...


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