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4 answers
4 votes
5k views
Is our genome decaying (see "Genetic Entropy"), and, if so, is this evidence for our genome being "young"?
6 votes

Regarding the reference to Lynch, actually reading this paper is illuminating (http://www.pnas.org/content/107/3/961.full). What Lynch is saying with regards to degeneration is that he and others feel ...

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2 answers
1 votes
305 views
Characters do not make the genus, but the genus gives the characters?
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5 votes

It has been a long time since, I've read The Origin of Species, but it sounds like the intent of the phrase is to suggest that the presence of similar characteristics in two species do not imply that ...

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4 answers
10 votes
1k views
How can insects survive without an adaptive immune system?
4 votes

There is not really a definitive explanation for why, although it's important to note that many mammalian pathogens are not adapted to insects and vice-versa. Insects need to survive insect pathogens, ...

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3 answers
5 votes
339 views
Can we knock out Caspase-9 *and* avoid breast cancer phenotype in our mouse model?
4 votes

The short answer is that it is likely a bad experiment; being that it would be expensive and is not likely to provide useful new information. The long answer (i.e. why) is identifying an interesting ...

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4 answers
3 votes
269 views
Can systemic intravascular thrombosis cause brain infarction?
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4 votes

This question seems to stem from a misunderstanding of the nature of the Blood-Brain-Barrier, the circulatory system of the brain and of thrombi. The BBB is describes differences in the structure of ...

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1 answers
2 votes
178 views
Why does T-cell Cancer Therapy require a large tumor mutanome?
3 votes

Understanding the link between the size of the tumor mutanome and its immunogenicity requires a basic understanding of T-cell development and regulation. When normal human cells degrade proteins via ...

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1 answers
0 votes
298 views
What is a selectively neutral genotypic change?
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2 votes

Mutations in DNA or RNA sequences do not necessarily result in significant changes in the functions of the proteins they encode (or in the case of RNA ribozymes, ribozyme function ). This is because, ...

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3 answers
4 votes
3k views
Why can't plasma proteins migrate from capillaries?
1 votes

Generally, for plasma proteins to enter the tissue space, they must be able to passively diffuse out of the vessel into the tissue. This requires sufficiently large gaps between the endothelial cells ...

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2 answers
1 votes
276 views
Punnet Square for Genotype Probabilities
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1 votes

Our germ cells are haploid, while our somatic cells are diploid. The diploid cells of a child result from the fusion of a paternal haploid germ cell and a maternal haploid germ cell. When these germ ...

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1 answers
3 votes
3k views
How is the subunit molecular weight different from the native molecular weight?
1 votes

Your question is answered in the paper, the protein likely exists as a homodimer in vivo and denaturation (such as performed with SDS PAGE -> Western Blot) separates the dimers into monomers: "To ...

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2 answers
2 votes
247 views
Career progression through biosafety levels?
0 votes

Here's a nice little walk-through by the CDC on Biosafety levels. Biosafety level reflects that potential risk microbes used (or potentially present in the case of human tissue samples) in the ...

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