Seanny123
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What is "irrational" drug/molecule design?
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According to "Drugs: From Discovery to Approval" by Rick Ng. The "rationality" of drug design refers to whether structure is used to inform the design. The Irrational approach: involves empirical ...

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Why is protein cyclisation desirable?
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3 votes

As described in the abstract of Synthetic Cross-linking of Peptides: Molecular Linchpins for Peptide Cyclization by Derda et al., protein cyclization improves: resistance to proteolytic degradation ...

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Relation between trigeminal and facial nerve in sympathetic response
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2 votes

Certain parts of the facial nerve cooperatively share structure of trigeminal nerve. For example, to reach the sublingual gland, the chorda tympani of the facial nerve joins the mandibular branch of ...

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What's the difference between Kd and IC50?
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1 votes

First, let's review the definitions of $K_d$ and $IC_{50}$. $K_d$ $K_d$ refers to the dissociation rate at equilibrium and is calculated by $\frac{K_{on}}{K_{off}}$. This is the rate at which the ...

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What is the purpose of an siRNA screen in drug discovery?
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1 votes

According to the Labome article "siRNAs and shRNAs: Tools for Protein Knockdown by Gene Silencing" siRNA does stand for small interfering RNA. siRNA is used to silence genes via mRNA ...

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Are cortical columns restricted to somatosensory cortical sections?
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1 votes

Cortical columns (also called minicolumns) are not limited to the somatosensory cortex. As shown in this paper (which discusses how the miniucolumns change in response to aging), it is also present in ...

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Why is the vermis of the cerebellum associated with speech?
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1 votes

Although speech production is in generally executed in the cerebral domain, the dysarthria resulting from damage of the vermous is a symptom of the resulting general muscle weakness. So yes, you get ...

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Lateral corticospinal tract and termination
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1 votes

The answer ends up being on the next page when discussing the ventral corticospinal tract. Many ventral corticospinal tract axons have branches that decussate in the spinal cord, similar to the ...

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Trade-offs between phage and yeast displays?
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0 votes

According to Creative Biolabs, the primary differences are: In the screening/panning step, yeast display is suitable for Fluorescence Activated Cell Sorting (FACS), allowing to sort out antibodies ...

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