Douglas Myers-Turnbull
  • Member for 7 years, 3 months
  • Last seen more than a month ago
  • Stanford, CA
How do we know that selective agonists are indeed selective?
3 votes

Unfortunately, it's really hard in the general sense. Even for FDA-approved drugs with well-characterized mechanisms of action, the binding profiles are incomplete. For GPCRs, it's you can run your ...

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B cell receptor editing
2 votes

The short answer is no. Here's a review article with some evidence: B cell receptor editing in tolerance and autoimmunity Section: Receptor Editing in Mice with Conventional Autoantibody Transgenes ...

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Is the innate immune system capable of identifying all foreign antigens?
Accepted answer
2 votes

TL;DR the huge block of text: The innate immune system only recognizes certain antigens, called PAMPs. The activate immune system usually requires the immune system, but it can get around this in ...

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Do cats produce DMT?
1 votes

Yes! Many mammals, including cats and humans, produce DMT in small amounts. DMT has been detected in blood and urine and is produced by the enzyme indolethylamine N‐methyltransferase (INMT). These do ...

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Do you know of any disease where HLA / MHC association discovery has led to better treatment or management?
1 votes

I don't know any true disease associations, but since this question still has no answers, I'll offer one... One class of associations you might be missing is difference in drug response. Patients ...

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Gene duplication and subfunctionalization
Accepted answer
1 votes

Suppose a gene performs two distinct functions 1 and 2, both of which are essential. We'll call this gene A, for ancestral gene. A duplication copies A to another locus. Now there are two genes, A ...

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