Timeline for What Produces the Postive Potenial in the lumen of the thick ascending loop of Henle?
Current License: CC BY-SA 4.0
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| when toggle format | what | by | license | comment | |
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| Mar 17, 2022 at 13:46 | comment | added | Bryan Krause♦ | @OmarShahaltough All potentials are relative; the potential inside the membrane and potential outside it are the same, just opposite sign. The apical membrane (left side) has an electrical gradient that is more negative inside, so pulls positive charge in. The basolateral membrane is the one on the right hand side of the diagram; since chloride can move freely on that side, there isn't the same negative gradient into the cell. If you sum these in series, the net result is a pumping of positive ions from the left side through to the right (paracellular diffusion). | |
| Mar 17, 2022 at 10:30 | comment | added | Omar Shahaltough | im sorry if i misunderstood but im not seeming to understand two things: 1. the relevance of the potential inside the cell when it comes to the potential outside of the cell, and 2. What exactly does "makes the basolateral membrane less negative mean"? | |
| Mar 16, 2022 at 23:33 | comment | added | Bryan Krause♦ | @OmarShahaltough Read the explanation in my answer; don't pay attention to the movement shown in the pumps and co-transporters, those don't matter. | |
| Mar 16, 2022 at 23:27 | comment | added | Omar Shahaltough | But what makes the lumen potential positive relative to the extracellular space on the basolateral side? as shown in the image, the paracellular diffusion is driven by that potential difference. yes chloride exits on basolateral side, but looking at the rest of the transporters it seems like the charges should balances out on each side of the cell. Am i missing something? | |
| Mar 16, 2022 at 20:28 | history | edited | Bryan Krause♦ | CC BY-SA 4.0 |
added 1 character in body
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| Mar 16, 2022 at 20:23 | history | answered | Bryan Krause♦ | CC BY-SA 4.0 |