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Apr 1, 2022 at 4:22 vote accept Retracted
Mar 31, 2022 at 21:13 comment added Retracted That is a good point, but I am not sure that, at least before all 64 codons were assigned, all codons were frozen. With an unused codon available the genetic code can change by 1. assigning an amino acid to the codon, 2. switching all proteins to the new codon, then 3. assigning something else to the newly free codon. The fact that the code can't be changed without destroying almost every protein doesn't come in to play until the codons are all being used. That implies that natural selection may have influenced the choice of many codons, even if as you point out it can't change them today.
Mar 31, 2022 at 20:07 history edited David CC BY-SA 4.0
A little honing to explain why met and trp may have been added late
Mar 31, 2022 at 17:58 history answered David CC BY-SA 4.0