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Apr 12, 2022 at 10:05 comment added Chris @jk-ReinstateMonica I think the prevalence of this mutation comes from the APOBEC-mediated mechanism. Why this is in place is unknown I think. I will try to see if I find some further information on it.
Apr 12, 2022 at 9:29 comment added Sir Cornflakes This is a great answer (+1) exhibing the mechanism behind the mutations, but it does not explain the prevalence of T-to-I mutations over A-to-V mutations.
Apr 11, 2022 at 17:31 history edited Chris CC BY-SA 4.0
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Apr 11, 2022 at 10:19 history edited Chris CC BY-SA 4.0
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Apr 11, 2022 at 9:46 history answered Chris CC BY-SA 4.0