Timeline for Which cells in our body perform lactic acid fermentation?
Current License: CC BY-SA 4.0
7 events
| when toggle format | what | by | license | comment | |
|---|---|---|---|---|---|
| May 18, 2023 at 17:29 | history | edited | David | CC BY-SA 4.0 |
Changed the ranking of brain and qualified by adding "astrocytes".
|
| May 18, 2023 at 17:28 | comment | added | David | @Patrick — Yes it looks pretty solid. The source I quote also talks about the "astrocyte–neuron lactate shuttle". This is not my area (as I always say), I just have a vague memory of things I have encountered and know how to search. I'll change it. The answer would be better with a paragraph after each entry, but there's only so much time one can devote to these things. | |
| May 18, 2023 at 11:31 | comment | added | Patrick | This article tells about lactate being the neuronal energy source. I am posting this to ask why you placed brain on the "somewhat less" category. Thus, it is hypothesized that the astrocytes produce lactate which is then taken up by the adjacent neurons and oxidized for fuel. | |
| May 18, 2023 at 11:20 | vote | accept | Patrick | ||
| May 18, 2023 at 10:55 | comment | added | David | The historical papers generally measured the production of lactate by tissues. This was assumed to be from pyruvate in a reaction catalysed by lactate dehydrogenase, and subsequent work confirms LDH as the sole enzyme producing lactate. The origin of the pyruvate may or may not be shown to be glycolysis, depending on the study (there are 60 years' worth of papers for you to follow up). However in many/most experiments glucose is the only source of carbohydrate precursor for pyruvate, so this is quite reasonable. In any case there are not a lot of alternative precursors for pyruvate. | |
| May 18, 2023 at 10:26 | comment | added | Patrick | This is answered on the basis that no other pathway other than anaerobic glycolysis produces lactic acid right? | |
| May 18, 2023 at 10:10 | history | answered | David | CC BY-SA 4.0 |