Timeline for What conditions are necessary for HPL (human pancreatic lipase) to activate?
Current License: CC BY-SA 3.0
16 events
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| Mar 26, 2012 at 21:06 | vote | accept | please delete me | ||
| Mar 22, 2012 at 18:18 | history | edited | Rory M |
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| Mar 21, 2012 at 15:45 | comment | added | Larry_Parnell | If a lipase did not need activation, there is the risk that it would digest membrane constituents before compartmentalization and secretion. I'd expect most lipases to have a signal peptide, which needs to be cleaved prior to activation. | |
| Mar 21, 2012 at 15:43 | answer | added | Larry_Parnell | timeline score: 6 | |
| Mar 21, 2012 at 14:32 | comment | added | shigeta | I wasn't aware that most lipases needed any activation at all. wikipedia says it is secreted from the pancreas in active form. It might be pH dependent because its a digestive enzyme, but most lipases are.... | |
| Mar 21, 2012 at 13:24 | history | reopened | Mad Scientist | ||
| Mar 21, 2012 at 13:12 | history | edited | please delete me | CC BY-SA 3.0 |
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| Mar 21, 2012 at 10:59 | history | closed | Mad Scientist | not a real question | |
| Mar 21, 2012 at 0:11 | comment | added | Miriam | Doesn't lingual lipase have an optimal pH around 4 - 5? That's why it can still continue its catalytic activity even in the stomach... | |
| Mar 20, 2012 at 14:13 | comment | added | Larry_Parnell | Which lipase do you have in mind? From which organism(s)? There are over 90 lipase genes in the human genome. | |
| Mar 20, 2012 at 4:26 | comment | added | please delete me | @MadScientist I was using a 10% lipase solution; that was all the information about the kind of lipase that I was given. | |
| Mar 20, 2012 at 4:25 | comment | added | please delete me | @Danielδ Oh my. That is almost exactly the experiment I did the other day, except I got no results. I'm wondering if my lipase was kind of smurfed. | |
| Mar 19, 2012 at 23:41 | history | tweeted | twitter.com/#!/StackBiology/status/181888226104057856 | ||
| Mar 19, 2012 at 18:18 | comment | added | Mad Scientist | There are several different lipases, you might want to specify which one you're interested in. It might help to add your motivation for asking this question, so that we might better understand what exactly you are looking for. | |
| Mar 19, 2012 at 17:25 | comment | added | Daniel | Check this out: 123helpme.com/view.asp?id=123079 | |
| Mar 19, 2012 at 17:15 | history | asked | please delete me | CC BY-SA 3.0 |