I think CVC lead to Pulmonary congestion and edema. They produce heavy, wet lungs.
Pulmonary changes include
- perivascular and interstitial edema, particularly in the interlobular septa;
- progessive edematous widening of alveolar septa; and
- accumulation of edema fluid in alveolar spaces. Hemosiderin into the edema fluid within the alveolar spaces, where they are phagocytosed and digested by macrophages, which store the iron recovered from hemoglobin in the form of hemosiderin. These hemosiderin-laden macrophages are telltale signs of previous pulmonary edemacontain Hemosiderin and are often referred to as heart failure cells.microhemorrhages
This answer is too extensive. ItNow, the progression of the disease to heart should be simplerdiscussed. I am not sure if hemosiderin can go directly from lungs to heart or if it has to travel through circulation and misses focusthen to left-side of lung.