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• Atrial fibrillation and Left atrial appendix is the source where thrombus can spread into the great circulation
• Patent Foramen Ovale and Stroke where risk factors anatomic variation (PFO size, ASA, eustachian valve anatomy), hemodynamic parameters, presence of venous thrombus identified through higher-sensitivity tests such as lower extremity/abdominal/pelvic MRI, and the presence of hypercoagulable genetic variables

• Atrial fibrillation and Left atrial appendix is the source where thrombus can spread into the great circulation
• Patent Foramen Ovale and Stroke where risk factors anatomic variation (PFO size, ASA, eustachian valve anatomy), hemodynamic parameters, presence of venous thrombus identified through higher-sensitivity tests such as lower extremity/abdominal/pelvic MRI, and the presence of hypercoagulable genetic variables

The systemic intravascular thombosis increases the risk of stroke, for example, through the two situations as described in Raoul's answer here but those are not sufficient for the accurate risk score of the stroke risk. The factors of stroke risk interact with each other so we cannot leave this question just only about intravascular thombosis and stroke risk, but must consider stroke risk more generally.

The systemic intravascular thombosis increases the risk of stroke, for example, through the two situations as described in Raoul's answer here but those are not sufficient for the accurate risk score of the stroke risk. The factors of stroke risk interact with each other so we cannot leave this question just only about intravascular thombosis and stroke risk, but must consider stroke risk more generally.

The systemic intravascular thombosis increases the risk of stroke through the two situations as described in Raoul's answer here. There are many mechanisms how the thrombus can increase the risk of stroke.

• Atrial fibrillation and Left atrial appendix is the most common source where thrombus can spread into the great circulation
• Patent Foramen Ovale and Stroke where risk factors anatomic variation (PFO size, ASA, eustachian valve anatomy), hemodynamic parameters, presence of venous thrombus identified through higher-sensitivity tests such as lower extremity/abdominal/pelvic MRI, and the presence of hypercoagulable genetic variables

BBB's permeability

The role of the permeability of the brain-blood barrier is unknown to me but it should not be passed normally. The following factors interact with the BBB's permeability

Cerebral Blood Flow and stroke

The Cerebral Blood Flow (CBF) interaction with the risk of stroke is unknown field

• Alcohol effects on CBF in subjects with low and high responses to alcohol, here.

• carbonated water increases CBF

• aging decreases CBF (standard textbook MRI pictures)

1. Stoll, Guido. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. 2009. Online available.
2. Homma, Shunichi, et al. Foramen Ovale and Stroke. 2005. Online available.

The systemic intravascular thombosis increases the risk of stroke, for example, through the two situations as described in Raoul's answer here but those are not sufficient for the accurate risk score of the stroke risk. The factors of stroke risk interact with each other so we cannot leave this question just only about intravascular thombosis and stroke risk, but must consider stroke risk more generally.

• Atrial fibrillation and Left atrial appendix is the source where thrombus can spread into the great circulation
• Patent Foramen Ovale and Stroke where risk factors anatomic variation (PFO size, ASA, eustachian valve anatomy), hemodynamic parameters, presence of venous thrombus identified through higher-sensitivity tests such as lower extremity/abdominal/pelvic MRI, and the presence of hypercoagulable genetic variables

BBB's permeability and Stroke risk

The interaction of the permeability of the brain-blood barrier with the stroke risk is much unknown. The following factors interact with the BBB's permeability

Cerebral Blood Flow (CBF) and stroke and Stroke Risk

CBF interaction with the risk of stroke is unknown field

• Alcohol effects on CBF in subjects with low and high responses to alcohol, here.
• carbonated water increases CBF
• aging decreases CBF (standard textbook MRI pictures)

1. Stoll, Guido. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. 2009. Online available.
2. Homma, Shunichi, et al. Foramen Ovale and Stroke. 2005. Online available.
3. Citings in the body of this question.