Timeline for Is cyanocobalamin toxic?
Current License: CC BY-SA 3.0
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| Apr 28, 2015 at 12:37 | history | edited | WYSIWYG | CC BY-SA 3.0 |
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| Apr 28, 2015 at 12:32 | comment | added | WYSIWYG | @user4779 enzymes are not magic molecules. If enzymes could do that easily then why should cyanide poisoning happen at all? Cyanide can be and is removed from cyanocobalamin when it is converted to active form but I assume that it would be very energy expensive and therefore won't happen in a large scale. | |
| Apr 28, 2015 at 12:23 | history | edited | WYSIWYG | CC BY-SA 3.0 |
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| Apr 28, 2015 at 7:29 | comment | added | user4779 | Wouldn't an enzyme be able to easily perform this synthesis regardless of how tightly bound it is? | |
| Apr 28, 2015 at 7:04 | comment | added | WYSIWYG | @user4779 In case of amygdalin the CN is not complexed with a metal. It is covalently bonded with carbon and is close to a hydrolyzable group. | |
| Apr 28, 2015 at 6:57 | comment | added | WYSIWYG | @MarchHo It should to a little extent but CN is much stronger ligand than others. And B12 bioavailability of cyanocobalamin is very low. | |
| Apr 28, 2015 at 6:56 | comment | added | March Ho | I believe CN- does in fact dissociate from cyanocobalamin, as otherwise it would not be bioavailable as vitamin B12. | |
| Apr 28, 2015 at 6:55 | comment | added | WYSIWYG | @user4779 Generally the bond between the Transition metal and cyanide is very strong. It would not easily dissociate. Even if it does, the minuscule concentration would not be toxic. For all practical purposes you can assume that CN- does not dissociate from the metal. Even potassium ferrocyanide K₄Fe(CN)₆ is non-toxic. | |
| Apr 28, 2015 at 6:43 | comment | added | user4779 | Interesting, but for the molecules of B12 that are bioactive, I believe the cyano group dissociates as free cyanide. Just curious if any such effects have been studied, as free cyanide also breaks off in Amygdalin and that has been linked to cyanide toxicity in comparable dosages I believe. | |
| Apr 28, 2015 at 6:41 | history | edited | WYSIWYG | CC BY-SA 3.0 |
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| Apr 27, 2015 at 10:21 | history | answered | WYSIWYG | CC BY-SA 3.0 |