Antibiotics stimulate the normal immuneEdited for Clarity:
In order to invoke a memory response, and illicit or create a memory response the same as a normal infection.
Antibiotics are recognized by B-Cells, there (part ofmust be interaction with the InnateAdaptive Immune System) which then process the compound into a presentable protein. Once the protein is presented by the B-Cell to a T-Cell (usually CD40+ "Helper" T-Cells), and the T-Cell then carries outinteraction must come in the response as normalform of a protein since the MHC receptors only respond to proteins.
A quirk of antibiotics isAntibiotics are usually smaller macromolecules that directly cause slower growth or kill the Hapten-Carrier affectmicrobe. Since stimulation ofThey will not create or illicit a memory response because they are not presented to the Adaptive Immune Systemimmune system to initiate the proper procedure, and may not be proteins and unable to be presented in the first place.
If you're asking about vaccines (T-Cellswhich was my inference before the edit) requires a protein, artificial antibiotics can be a combination ofthen they stimulate what is basically the Hapten; a moleculesame memory creation mechanisms that acts as the counterpartnormal infections do. Antibody counterparts recognized by B-Cell ReceptorsCells are paired with proteins from the disease you want to immunize against, called the Hapten and Carrier respectively. Then the Carrier; a protein that can be presented byis processed via the B-CellCells, presented to the T-Cell which the T-Cell will then use as the template for recognizing the antigen.
Once the antigen/infection is appropriately recognizedCells, the Antibiotics no longer play any role. They are essentially a big red flag saying "You're infected with THIS" and then the usual ramp-up or recalla memory response occursis made.
-Path 5050 "Basic Immunology" notes My apologies if the previous answer was more ambiguous.