Timeline for Is "exhaustion" of the Hodgkin-Huxley membrane at constant stimulation a real phenomenon?
Current License: CC BY-SA 3.0
7 events
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| Jan 5, 2012 at 13:25 | comment | added | yamad | From my point of view, whether or not this phenomenon requires non-physiological input to the cell is not relevant to the question. This is not an artifact of the model. In fact, the model predicts the behavior of a real neuron. | |
| Jan 2, 2012 at 23:10 | comment | added | walkytalky | @Tim For that experiment, I broadly stand by my guess. With sufficient current injection you could overwhelm the oscillatory behaviours of the channel population. It would, however, be interesting to see how closely the real current needed for that matched the model prediction. | |
| Jan 2, 2012 at 23:04 | comment | added | user24 | I don't find it improbable that this could be a known problem with the model or a known behaviour of the real membrane. | |
| Jan 2, 2012 at 23:02 | comment | added | user24 | The question is rather how well the model describes reality in one specific aspect. A way to check would be to clamp a squid giant axon the way Hodgkin and Huxley did, apply a constant current of sufficient amplitude, and measure the membrane potential. | |
| Jan 2, 2012 at 22:58 | comment | added | walkytalky | @Tim In which case you probably need to be more specific about the experiment you're proposing. Your question seems to boil down to how fully the H-H model describes the behaviour of an actual axon membrane propagating APs. (There's an auxiliary issue of how well your sim implements the model, but let's shelve that for now.) Not having done the experiment, I can only guess. My intuition is that it would be possible to drive a real membrane to steady state if you're sufficiently aggressive about it, but that doing so would not demonstrate anything meaningful. | |
| Jan 2, 2012 at 9:55 | comment | added | user24 | Thanks for your input. I'm interested in what would happen to a real membrane, though, not whether the situation is likely to occur naturally. | |
| Jan 2, 2012 at 1:51 | history | answered | walkytalky | CC BY-SA 3.0 |