Timeline for Minimum size for a peptide/protein to be immunogenic in human?
Current License: CC BY-SA 3.0
5 events
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| Apr 25, 2017 at 15:40 | vote | accept | biofan | ||
| Feb 16, 2016 at 16:56 | comment | added | CKM | I will attempt to find the resources, but from what I understood about tripeptide antigens is they're considered non-immunogenic as they typically can't elicit a primary immune response, whereas they're perfectly capable of somehow activating a DTH reaction. So in that sense they would act more like a nucleic acid or lipid in that they're largely non-immunogenic haptens. I'm unsure if that would end up out-of-scope for OPs question about immunogenic peptides. | |
| Feb 16, 2016 at 16:42 | comment | added | WYSIWYG |
Can small peptides can act like haptens? Can you add some details on this, if you know? MHC peptide length may not really mean the smallest immunogenic size. In fact, very recently I heard someone talk about an antibody against a tripeptide for doing immunoprecipitation. I asked the speaker if he really meant an antibody against a general tripeptide epitope and he confirmed so. I forgot which tripeptide it was but it was supposedly generated after a tryptic digest of the ubiquitin tag (so possibly the RGG tripeptide). Even the well known FLAG-tag (DYKDDDDK) is an octapeptide.
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| Feb 16, 2016 at 15:55 | history | edited | CKM | CC BY-SA 3.0 |
added 230 characters in body
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| Feb 16, 2016 at 15:45 | history | answered | CKM | CC BY-SA 3.0 |