Timeline for Why does meiotic recombination disrupt the independent assortment of genes on the same chromosome?
Current License: CC BY-SA 3.0
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| Jul 19, 2016 at 21:49 | vote | accept | john01dav | ||
| Apr 20, 2016 at 2:35 | comment | added | Remi.b | Yes, recombination has nothing to do with genes. Not however that recombination rate per nucleotide tend to be lower in regions of high gene density. Two closely linked loci (might be genes at these loci) are less likely to segregate independently as it is less likely that a recombination event occurs in between them (you seem to say the opposite in your comment). | |
| Apr 20, 2016 at 2:32 | comment | added | john01dav | Are you saying that when a recombination event occurs (I am assuming this is the same thing as a cross-over, please correct me if I am wrong), the actual genetic material being moved around is just a random contiguous chunk that has no bearing on the borders between genes? If so, then am I correct in assuming that two closer genes are more likely to be swapped together since a single recombination event will more likely encompass both of those genes? If so, I would think an answer containing that information would be best. | |
| Apr 20, 2016 at 1:51 | comment | added | Luigi | By "two loci" Remi.b means two loci on the same chromosome. Simple example: (a) ------------X--X----------------- compared to (b) -X----------------------------X- , if Xs denote genes, it is much more likely for the genes in (a) to remain on the same chromosome than for the genes in (b) assuming a random choice of recombination point. Although recombination is not actually random, this example holds in vivo. | |
| Apr 20, 2016 at 1:38 | comment | added | mdperry | Recombination has nothing to do with genes. The genes happen to be genetic markers arrayed along the physical chromosome. Meiotic recombination, in general, occurs after a double-stranded break has been formed in one of the chromosomes. One way to repair this break is to form a crossover. When crossovers are repaired by the cell this can result in recombination (alternatively it can result in gene conversion). If you have several heterozygotic genetic markers on the chromosome then you can score the progeny and possibly map where the crossover occurred. | |
| Apr 20, 2016 at 1:34 | comment | added | Remi.b | I don't understand what you mean. You say "recombination of one gene". What does it mean? A recombination (or cross-over) is the process by which homologous chromosomes exchange genetic material. This process allows for higher independence of assortment of linked loci. The more closely linked are two loci, the less likely it is that a recombination event will separate them. | |
| Apr 20, 2016 at 0:57 | comment | added | john01dav | Doesn't recombination always occur between two alleles on homologous chromosomes of the same gene? Also, doesn't a recombination of one gene not effect another? | |
| Apr 20, 2016 at 0:54 | vote | accept | john01dav | ||
| Apr 20, 2016 at 0:55 | |||||
| Apr 20, 2016 at 0:50 | history | answered | Remi.b | CC BY-SA 3.0 |