Timeline for how to quantify toxicity
Current License: CC BY-SA 3.0
15 events
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| Jun 9, 2016 at 8:57 | comment | added | WYSIWYG | @Rishika How is toxicity experimentally measured is a different question. Your comments are not actually asking for clarifications but asking new questions. Either edit your question to add these aspects or ask another question. Moreover, try reading about LD50/Lethal dose on wikipedia or other online resources instead of simply asking a user to explain it. | |
| Jun 9, 2016 at 8:52 | comment | added | WYSIWYG | A small note: There are some other measures too such as Maximum Tolerated Dose, Minimum Lethal Dose, therapeutic index etc. | |
| Jun 9, 2016 at 5:27 | comment | added | TreeHouse196 | @Rishika I am not sure I quite understand your question. If you want to know how LD50 is calculated, the LD50 value is obtained experimentally. If you want to familiarize yourself with the methods used to calculate LD50 values, I would read some articles that report research doing that. Here is an article I found with a quick pubmed search where the LD50 of several compounds was calculated in silkworms: jstage.jst.go.jp/article/ddt/10/1/10_2016.01025/_pdf. If this does not answer your question, I would encourage you to post it as a new question on stack exchange. | |
| Jun 9, 2016 at 4:49 | comment | added | girl101 | no my question is whichever value is the correct value, how can one get that correct value. How is the quantity of the toxin related to the functionality of the host? | |
| Jun 8, 2016 at 20:42 | review | Suggested edits | |||
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| Jun 8, 2016 at 10:02 | history | edited | Chris♦ | CC BY-SA 3.0 |
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| S Jun 8, 2016 at 9:59 | history | suggested | Ebbinghaus | CC BY-SA 3.0 |
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| Jun 8, 2016 at 9:39 | review | Suggested edits | |||
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| Jun 8, 2016 at 6:08 | vote | accept | girl101 | ||
| Jun 8, 2016 at 6:08 | history | edited | TreeHouse196 | CC BY-SA 3.0 |
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| Jun 8, 2016 at 6:03 | history | edited | TreeHouse196 | CC BY-SA 3.0 |
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| Jun 8, 2016 at 5:57 | comment | added | TreeHouse196 | It means that when they were testing the drug on animals, 50% of the animals tested died when given the dose. So, if the LD50 of X is 1 mg/kg in mice when ingested orally, then 50% of mice can be expected to die if they consume 1 mg of X orally for every 1 kg of their own mass. | |
| Jun 8, 2016 at 5:55 | history | edited | TreeHouse196 | CC BY-SA 3.0 |
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| Jun 8, 2016 at 5:55 | comment | added | girl101 | "needed to kill 50% of the organisms of a species tested", what does this mean? | |
| Jun 8, 2016 at 5:45 | history | answered | TreeHouse196 | CC BY-SA 3.0 |