Timeline for Understanding Hodgkin-Huxley's model and activation variables
Current License: CC BY-SA 3.0
15 events
| when toggle format | what | by | license | comment | |
|---|---|---|---|---|---|
| Jan 18, 2020 at 8:12 | vote | accept | Hans-Peter Stricker | ||
| Dec 14, 2017 at 8:46 | comment | added | Hans-Peter Stricker | Let us continue this discussion in chat. | |
| Dec 13, 2017 at 17:11 | comment | added | Bryan Krause♦ | Since you seem particularly interested in ion channels lately, here is a whole list of models people have implemented in NEURON to demonstrate the effects of dozens of channels: senselab.med.yale.edu/ModelDB/ModelList.cshtml?id=3540 | |
| Dec 13, 2017 at 17:08 | comment | added | Bryan Krause♦ | senselab.med.yale.edu/modeldb/showModel.cshtml?model=5426 there are many premade models for NEURON like this one; frankly if you aren't willing to take the time then I feel a bit like I'm wasting my own time trying to answer your questions - it would take less time than I have spent answering questions to go through the tutorials and try out tweaking an existing simulation. | |
| Dec 13, 2017 at 16:41 | comment | added | Hans-Peter Stricker | Yes, you did, and yes, I had a look at NEURON, but unfortunately it's not a tool I could use out of the box: it needs a good understanding of terminology, theory and models (naturally!) but also of sensible variables and of the tool itself. Not so easy for someone like me (with not so much time). Thanks anyway. | |
| Dec 13, 2017 at 15:51 | comment | added | Bryan Krause♦ | I believe I've suggested the NEURON simulation environment to you several times. | |
| Dec 13, 2017 at 7:07 | comment | added | Hans-Peter Stricker | That's what I am after, doing my own. Or do you know some impressive and instructive simulations in the public? | |
| Dec 13, 2017 at 1:27 | comment | added | Bryan Krause♦ | "to see how action potentials happen to be created (beyond a not so well-defined threshold), or how being open (of a channel) cannot follow fast changing voltages" - all of these things can be answered with simulations. | |
| S Dec 13, 2017 at 1:21 | history | suggested | Hans-Peter Stricker | CC BY-SA 3.0 |
Removed some duplications
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| Dec 13, 2017 at 1:09 | comment | added | Hans-Peter Stricker | Thanks explicitly and especially for your link to Linear time-invariant theory, which was new to me. | |
| Dec 13, 2017 at 1:02 | comment | added | Hans-Peter Stricker | If you are interested in a preview: send an email to [email protected]. | |
| Dec 13, 2017 at 0:59 | comment | added | Hans-Peter Stricker | With regard to $\tau(V)$: It's all about the inertia of gates, let it be activation, inactivation, or deactivation gates. I never found time constants being called "inertia coefficients" or the like, but in the case of ion channels, this would hit the nail on the head. (Note, how inertia has to do with delay.) | |
| Dec 13, 2017 at 0:31 | comment | added | Hans-Peter Stricker | Thanks for your answer (which I edited slightly)! Please let me announce a reply to your answer which will show that it is definitely worth the effort to obtain explicit solutions for $m(t)$ (and to play around with them). Among other things: to see how action potentials happen to be created (beyond a not so well-defined threshold), or how being open (of a channel) cannot follow fast changing voltages.Please stay tuned! | |
| Dec 13, 2017 at 0:23 | review | Suggested edits | |||
| S Dec 13, 2017 at 1:21 | |||||
| Dec 12, 2017 at 18:58 | history | answered | Bryan Krause♦ | CC BY-SA 3.0 |