Timeline for Does the NMDA antagonist, Memantine that's used to prevent Excitotoxicity cause brain damage?
Current License: CC BY-SA 3.0
8 events
| when toggle format | what | by | license | comment | |
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| Feb 12, 2013 at 8:50 | comment | added | blep | Yes, I did mean the hallucinations. | |
| Feb 12, 2013 at 8:10 | comment | added | Josh Pinto | Ah, thanks, I assume you're talking about hallucinations because it makes the link between its NMDA antagonist activity and potential brain damage more clear by demonstrating that it has one of the effects characateristic of NMDA antagonists, i.e. hallucinations. | |
| Feb 12, 2013 at 7:57 | comment | added | blep | N is commonly used to refer to sample size (at least among the biologists that I've spoken with). The article I linked is a case study of 3 individuals. My point is that this is an extremely small number of individuals with documented adverse affects to memantine. If you want to read the article, you can read the 1 page preview (as an image)...the whole article happens to be 1 page. | |
| Feb 12, 2013 at 7:55 | comment | added | Josh Pinto | What do you mean by N=3? | |
| Feb 12, 2013 at 7:04 | comment | added | blep | @BrentonHorne Apparently, memantine might cause hallucinations in humans (N=3): http://jnnp.bmj.com/content/78/5/546.1.short | |
| Feb 12, 2013 at 5:21 | comment | added | Josh Pinto | Thanks, mate. That's helpful for me, of course in human studies would be more helpful but c'mon there's no such studies on the most widely-used NMDA antagonists like ketamine and PCP so I can hardly expect it for memantine -- a drug I had trouble finding evidence even in rodents. | |
| Feb 12, 2013 at 5:20 | vote | accept | Josh Pinto | ||
| Feb 12, 2013 at 5:04 | history | answered | blep | CC BY-SA 3.0 |