Timeline for Meaning of PAM matrix values
Current License: CC BY-SA 4.0
15 events
| when toggle format | what | by | license | comment | |
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| Mar 23, 2019 at 12:30 | history | edited | David | CC BY-SA 4.0 |
Changed unacceptable Help me title
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| S Mar 23, 2019 at 10:53 | history | suggested | Maxim Kuleshov |
Added a tag
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| Mar 23, 2019 at 6:55 | answer | added | perfidious pidgeon | timeline score: 1 | |
| Mar 23, 2019 at 1:35 | review | Close votes | |||
| Mar 23, 2019 at 11:56 | |||||
| Mar 23, 2019 at 1:17 | review | Suggested edits | |||
| S Mar 23, 2019 at 10:53 | |||||
| Mar 22, 2019 at 22:06 | comment | added | Anindya | Let us continue this discussion in chat. | |
| Mar 22, 2019 at 22:02 | comment | added | Anindya | en.m.wikipedia.org/wiki/Point_accepted_mutation?wprov=sfla1 | |
| Mar 22, 2019 at 22:00 | comment | added | David | No. Not in this context. Do as I say and search. | |
| Mar 22, 2019 at 21:59 | comment | added | Anindya | Accepted mutations are those that are accepted by nature, for example a hydrophobic amino acid substituted by another similar hydrophobic aa which does not negatively hamper with the protein structure and thus naturally selected. Any lethal mutations or silent mutations won't be part of accepted mutation. | |
| Mar 22, 2019 at 21:57 | comment | added | David | No. The terminology is difficult even for English native speakers. The key is what an “accepted” mutation is. Try Wikipedia or other sources that explain that. I’m on vacation so can’t actually check. Search for “accepted point mutation” perhaps. | |
| Mar 22, 2019 at 21:54 | comment | added | Anindya | English is not my first language, so, may be a little different set of words might be helpful for me to understand what really is going on. that's all | |
| Mar 22, 2019 at 21:53 | comment | added | Anindya | I used Xiong's and Jhumur Ghosh's bioinformatics books. they both explain how the matrix are made pretty well but my confusion is what I stated in my question. Page 148 Jhumur Ghosh's book states that the PAM 100 matrix corresponds to 100 accepted mutations per 100 residue. So, shouldn't it be the highest available matrix where the entire sequence is different. it clearly states there is 100% change in 100 amino acids after all. but then it also states one residues can also change more than once. how come one single residue can change multiple times when I am comparing two sequences only. | |
| Mar 22, 2019 at 21:42 | comment | added | David | What attempt have you made to find the answer to this frequently asked question on line? Please read the help on asking good questions. Tell us what pages you have consulted and why you do not understand the explanation. Then we can help. | |
| Mar 22, 2019 at 21:37 | history | edited | Anindya | CC BY-SA 4.0 |
edited title
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| Mar 22, 2019 at 21:31 | history | asked | Anindya | CC BY-SA 4.0 |