Timeline for How are drugs distributed in regards to bone marrow?
Current License: CC BY-SA 4.0
10 events
| when toggle format | what | by | license | comment | |
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| May 25, 2021 at 12:08 | history | bumped | CommunityBot | This question has answers that may be good or bad; the system has marked it active so that they can be reviewed. | |
| Jan 25, 2021 at 12:00 | history | bumped | CommunityBot | This question has answers that may be good or bad; the system has marked it active so that they can be reviewed. | |
| Dec 26, 2020 at 11:43 | answer | added | mhh | timeline score: 1 | |
| Apr 25, 2019 at 15:56 | history | edited | Roby Vicary | CC BY-SA 4.0 |
added 51 characters in body; edited title
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| Apr 25, 2019 at 12:39 | comment | added | WYSIWYG | @RobyVicary Vd is an indicative of the drug solubility. Drugs with high water solubility are enriched in blood whereas the ones high lipid solubility (and hence low water solubility) end up in adipose. There are other factors too apart form solubility. However, pharmacodynamics is not simply determined by drug solubility. Your question should be rephrased and perhaps you should ask how much percentage of a certain drug in blood is present in bone marrow. Most bone marrows have good vasculature; so I would guess that bone marrow should have almost the same concentration as the blood. | |
| Apr 25, 2019 at 3:13 | comment | added | Roby Vicary | Thank-you for letting me know, but can you explain further? I know that the volume of distribution is unique to a drug, but high volumes of distribution indicate the drug is preferentially stored in adipose; and that low volumes indicate it is retained in the blood. I am asking where the bone marrow would fit in the progression above. i.e. Are low Vd drugs stored in blood AND bone marrow? or Does the bone marrow retain drugs with a similar capacity to the VRG? | |
| Apr 24, 2019 at 13:29 | comment | added | WYSIWYG | Volume of distribution is a property of the drug and not the tissue. Your question is unclear. | |
| Apr 24, 2019 at 11:50 | review | Close votes | |||
| May 10, 2019 at 3:05 | |||||
| Apr 24, 2019 at 11:30 | comment | added | Arsak | I guess this is about the distribution of a drug within the body? | |
| Apr 24, 2019 at 7:04 | history | asked | Roby Vicary | CC BY-SA 4.0 |