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Ca<sup>2+</sup> Replaced slang headings

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edited Jul 21, 2021 at 11:00

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TL, DR:Short Answer

The Long-WindedLong Answer

The calcium ion (Ca2+Ca²⁺) gradient is established by an extracellular concentration > intracellular concentration (at rest) across the neuron’s cellular membrane at the terminal end (pre-synaptic neuron). Le Chatelier’s Principle (equilibrium) indicates that potential energy will build from the unresolved Ca2+ gradient, which will drive flux from high to low when given the chance.

The Ca2+Ca²⁺ resistance is established (mainly) by voltage-gated Ca2+Ca²⁺ (VG-Ca2+Ca²⁺) channels. These are also on the terminal end of the neuron (pre-synaptic), and resistance is determined specifically on if channels are open or closed (closed at rest), AND the number of VG-Ca2+Ca²⁺ channels present on the membrane.

To create an influx, gradient has to become > than resistance. Once an action potential travels down the axon and depolarization occurs at our local site, the increase in membrane potential (voltage) opens the VG-Ca2+Ca²⁺ channels, thus decreasing resistance. Influx of Ca2+Ca²⁺ into the axon terminal occurs.

One type of glial cells are called astrocytes, or astroglia, and a couple of their many functions includes distributing nutrients to nervous tissue, and maintenance of (neuronal) extracellular ion concentrations, including Ca2+Ca²⁺. Astrocytes also have access to blood vessels, giving them access to nutrients (supposedly like calcium ions).

Ion flow from source is fairly constant (in a healthy individual), the biggest regulator of ion flux into the pre-synaptic neuron will be the actual VG-Ca2+Ca²⁺ channels.

Ca2+Ca²⁺ outside of the (pre-synaptic) neuron’s axon terminal will influx when depolarization reaches the axon terminal, as that decreases Ca2+Ca²⁺ resistance across the membrane:

Action potential travels down axon
Depolarization occurs at axon terminal
Increase in membrane potential (voltage)
VG-Ca2+Ca²⁺ channels open
Ca2+Ca²⁺ flux down its electrochemical gradient (influx, pre-synaptic neuron)

Ca2+Ca²⁺, once inside axon terminal, interacts with SNAP and SNARE proteins to shuttle vesicles containing neurotransmitters to the synaptic cleft (Ca2+Ca²⁺ - regulated exocytosis).

TL, DR:

The Long-Winded Answer

The calcium ion (Ca2+) gradient is established by an extracellular concentration > intracellular concentration (at rest) across the neuron’s cellular membrane at the terminal end (pre-synaptic neuron). Le Chatelier’s Principle (equilibrium) indicates that potential energy will build from the unresolved Ca2+ gradient, which will drive flux from high to low when given the chance.

The Ca2+ resistance is established (mainly) by voltage-gated Ca2+ (VG-Ca2+) channels. These are also on the terminal end of the neuron (pre-synaptic), and resistance is determined specifically on if channels are open or closed (closed at rest), AND the number of VG-Ca2+ channels present on the membrane.

To create an influx, gradient has to become > than resistance. Once an action potential travels down the axon and depolarization occurs at our local site, the increase in membrane potential (voltage) opens the VG-Ca2+ channels, thus decreasing resistance. Influx of Ca2+ into the axon terminal occurs.

One type of glial cells are called astrocytes, or astroglia, and a couple of their many functions includes distributing nutrients to nervous tissue, and maintenance of (neuronal) extracellular ion concentrations, including Ca2+. Astrocytes also have access to blood vessels, giving them access to nutrients (supposedly like calcium ions).

Ion flow from source is fairly constant (in a healthy individual), the biggest regulator of ion flux into the pre-synaptic neuron will be the actual VG-Ca2+ channels.

Ca2+ outside of the (pre-synaptic) neuron’s axon terminal will influx when depolarization reaches the axon terminal, as that decreases Ca2+ resistance across the membrane:

Action potential travels down axon
Depolarization occurs at axon terminal
Increase in membrane potential (voltage)
VG-Ca2+ channels open
Ca2+ flux down its electrochemical gradient (influx, pre-synaptic neuron)

Ca2+, once inside axon terminal, interacts with SNAP and SNARE proteins to shuttle vesicles containing neurotransmitters to the synaptic cleft (Ca2+ - regulated exocytosis).

Short Answer

Long Answer

The calcium ion (Ca²⁺) gradient is established by an extracellular concentration > intracellular concentration (at rest) across the neuron’s cellular membrane at the terminal end (pre-synaptic neuron). Le Chatelier’s Principle (equilibrium) indicates that potential energy will build from the unresolved Ca2+ gradient, which will drive flux from high to low when given the chance.

The Ca²⁺ resistance is established (mainly) by voltage-gated Ca²⁺ (VG-Ca²⁺) channels. These are also on the terminal end of the neuron (pre-synaptic), and resistance is determined specifically on if channels are open or closed (closed at rest), AND the number of VG-Ca²⁺ channels present on the membrane.

To create an influx, gradient has to become > than resistance. Once an action potential travels down the axon and depolarization occurs at our local site, the increase in membrane potential (voltage) opens the VG-Ca²⁺ channels, thus decreasing resistance. Influx of Ca²⁺ into the axon terminal occurs.

One type of glial cells are called astrocytes, or astroglia, and a couple of their many functions includes distributing nutrients to nervous tissue, and maintenance of (neuronal) extracellular ion concentrations, including Ca²⁺. Astrocytes also have access to blood vessels, giving them access to nutrients (supposedly like calcium ions).

Ion flow from source is fairly constant (in a healthy individual), the biggest regulator of ion flux into the pre-synaptic neuron will be the actual VG-Ca²⁺ channels.

Ca²⁺ outside of the (pre-synaptic) neuron’s axon terminal will influx when depolarization reaches the axon terminal, as that decreases Ca²⁺ resistance across the membrane:

Action potential travels down axon
Depolarization occurs at axon terminal
Increase in membrane potential (voltage)
VG-Ca²⁺ channels open
Ca²⁺ flux down its electrochemical gradient (influx, pre-synaptic neuron)

Ca²⁺, once inside axon terminal, interacts with SNAP and SNARE proteins to shuttle vesicles containing neurotransmitters to the synaptic cleft (Ca²⁺ - regulated exocytosis).

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created Jul 16, 2021 at 8:57

Fuzzy Bee

TL, DR:

Extracellular calcium ions’ “source” are probably cells called astrocytes that connect to both neurons and blood vessels.

Calcium ions outside the pre-synaptic neuron are high in concentration, but since they are polar molecules they cannot passively diffuse in, where they are low in concentration, so they stay stuck outside the neuron.

Voltage-gated calcium ion channels are closed at rest. These channels will open when depolarization occurs, as the membrane reaches a high-enough voltage threshold. Calcium ions rush in when these channels open. These voltage-gated channels are the primary regulator of calcium ion pre-synaptic neuron influx.

Calcium ions, once inside the neuron, will be used to release neurotransmitters into synaptic cleft.

The Long-Winded Answer

What determines the influx of calcium ions in these channels?

Whenever dealing with flux, it’s helpful to start with what determines the flux rate of anything:

Rate of flux ∝ gradient / resistance

To create an influx, gradient has to become > than resistance. Once an action potential travels down the axon and depolarization occurs at our local site, the increase in membrane potential (voltage) opens the VG-Ca2+ channels, thus decreasing resistance. Influx of Ca2+ into the axon terminal occurs.

Where are the ions coming from and what is their source?

Neurons are the flashy & exciting (no pun intended) cells in the nervous system, but to answer this question we must acknowledge that glial cells exist.

Neuroglia, glia, or glial cells are cells that DO NOT produce electrical impulses, but are cells within the nervous system.

One type of glial cells are called astrocytes, or astroglia, and a couple of their many functions includes distributing nutrients to nervous tissue, and maintenance of (neuronal) extracellular ion concentrations, including Ca2+. Astrocytes also have access to blood vessels, giving them access to nutrients (supposedly like calcium ions).

Research on the specifics is very up-and-coming, so it is difficult to find much on it. We know calcium is coming from blood (crossing the blood-brain barrier), glial networks (including astrocytes) distribute nutrients, and astrocytes specifically are tied to extracellular neuronal ion homeostasis.

If you are interested in researching this further, the connection (and network) of a neuron to its blood supply is called neurovascular coupling.

Image: a neurovascular coupling

Is the influx determined by the source by changing the ion flow, or the ion flow is constant and the influx of ions into the synapse is only regulated by opening/closing of the channels?

Ion flow from source is fairly constant (in a healthy individual), the biggest regulator of ion flux into the pre-synaptic neuron will be the actual VG-Ca2+ channels.

Ca2+ outside of the (pre-synaptic) neuron’s axon terminal will influx when depolarization reaches the axon terminal, as that decreases Ca2+ resistance across the membrane:

Action potential travels down axon
Depolarization occurs at axon terminal
Increase in membrane potential (voltage)
VG-Ca2+ channels open
Ca2+ flux down its electrochemical gradient (influx, pre-synaptic neuron)

Ca2+, once inside axon terminal, interacts with SNAP and SNARE proteins to shuttle vesicles containing neurotransmitters to the synaptic cleft (Ca2+ - regulated exocytosis).

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