Normally when drugs are administered to the blood of a mammalian subject, it is done intravenously--the needle being inserting into a vein. One potential problem with this is that the veins contain the exhausted blood which is returning to the liver and spleen. This is potentially disadvantageous because these organs could absorb the drug or be damaged by it.

It would seem more advantageous to introduce a drug to the arterial system, such as the aorta, so that the drug flows outwards to all parts of the body before returning to the filtering organs of the body.

Is this type of drug administration a known procedure. If so, why is not more generally used?