As we know during pregnancy predominant hormone is progesterone which is at early pregnancy about first 3-4 months produce by corpus luteum of pregnancy together with estrogen after that placenta can make its own progesterone with estrogen till birth but for initiation of labour estrogen go up and progesterone should go down because it prevents uterine contraction. Does anyone know mechanism of suppressing of progesterone and rising of estrogen before onset of labour ? In other word mechanism of initiation of labour ?


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