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Maria
Maria
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My plant extract (ethyl acetate fraction) seems to have two different effects depending on the cell/cell line it's being tested on. On liver cancer cells (HepG2), it is moderately cytotoxic. But on lymphocytes and macrophages, it helps increase their proliferation. Is this really possible? What do you think is the possible explanation for this?

I've been trying to find studies that might have similar results as mine, but none so far. I found one study wherein their extract both exhibited anti-proliferative effects on both cancer cells and fibroblasts. However, the effect is much stronger on cancer cells.

My plant extract seems to have two different effects depending on the cell/cell line it's being tested on. On liver cancer cells (HepG2), it is moderately cytotoxic. But on lymphocytes and macrophages, it helps increase their proliferation. Is this really possible? What do you think is the possible explanation for this?

I've been trying to find studies that might have similar results as mine, but none so far. I found one study wherein their extract both exhibited anti-proliferative effects on both cancer cells and fibroblasts. However, the effect is much stronger on cancer cells.

My plant extract (ethyl acetate fraction) seems to have two different effects depending on the cell/cell line it's being tested on. On liver cancer cells (HepG2), it is moderately cytotoxic. But on lymphocytes and macrophages, it helps increase their proliferation. Is this really possible? What do you think is the possible explanation for this?

I've been trying to find studies that might have similar results as mine, but none so far. I found one study wherein their extract both exhibited anti-proliferative effects on both cancer cells and fibroblasts. However, the effect is much stronger on cancer cells.

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Maria
Maria
  • 29
  • 2

Is it possible for a plant extract to have different effects, depending on the type of cell line it was tested on?

My plant extract seems to have two different effects depending on the cell/cell line it's being tested on. On liver cancer cells (HepG2), it is moderately cytotoxic. But on lymphocytes and macrophages, it helps increase their proliferation. Is this really possible? What do you think is the possible explanation for this?

I've been trying to find studies that might have similar results as mine, but none so far. I found one study wherein their extract both exhibited anti-proliferative effects on both cancer cells and fibroblasts. However, the effect is much stronger on cancer cells.