This is an open-ended question and will be impossible to correctly answer. I am voting "to close as too broad". Note also that the question in the title is not the same as the question in the post.
But I still wanted to give you some information that may help you. Here are just a few examples for which knowing gene density matters.
Background selection is the process by which purifying selection reduces heterozygosity at nearby loci. Knowing the density (and positions) of genes (and other sequences potentially under selection such as regulatory sequences) is essential to understand the variation of background selection throughout the genome. Being able to design maps of variation of background selection throughout the genome is essential to improve our ability to detect local adaptation and positive selection as background selection leaves similar genetic signature.
The evolution of the genome size is in itself of interest to evolutionary biologists. Species having large genomes ave large genomes mainly due to repetitive neutral sequences. As such the question of gene density is essential to understand the evolution of genome size.
The gene density varies throughout the genome (with a variance greater than the mean, that is it does not follow a Poisson distribution). Understanding the evolution of gene density at different regions is of interest to many. Note that interaction effects among genes also depend on their physical distance.