For synthesis of one molecule of glucose,six turns of calvin cycle are required.

One molecule of carbon dioxide combines with ribulose bisphosphate (RuBP) to form a stable product of two molecules of phosphoglycerate (PGA). This is called carboxylation. Then 2 molecules of PGA undergoes reduction to form 2 molecules of phosphoglyceraldehyde (PGAL).

My question is whether there 2 molecules of PGAL goes in the regeneration of RuBP or in the synthesis of glucose.

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    $\begingroup$ Your question is not clear. "is the reaction stopped at PGAL ... till 12 moleules of it are not produced" --- what do you mean? Which reaction, there are several reactions in the cycle? Where does your number 12 molecules of PGAL come from? What do you mean by "are not produced"? Please elaborate and explain. $\endgroup$ – Roland Feb 26 '17 at 11:45
  • $\begingroup$ I have edited the question. $\endgroup$ – RuBisCO Feb 26 '17 at 13:01
  • $\begingroup$ @AliceD@canadianer@James@another'Homo sapien'@Chris. I have edited the question.Please can u specify which part u all have not understood.And a good answer is also given by Roland which answered my question.So I don't get it what u all have not understood $\endgroup$ – RuBisCO Feb 26 '17 at 19:31
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    $\begingroup$ Moderators, I also think this question was closed too quickly. Initially it was unclear, but I think it is now perfectly valid. I'm voting to reopen. $\endgroup$ – Roland Feb 26 '17 at 20:59

The quick answer is "both", but the stoichiometry is not 1-to-1. The stoichiometry of the calvin cycle doesn't add up when thinking about a single molecules making one "turn" of the cycle. There is only one carbon (CO2) added, but three carbons (in PGAL) leave, which obviously cannot work.

What's happening is that multiple molecules are processed at the same time. The cycle is of course just a set of enzymes that continually catalyze their reactions, so there are always lots of molecules available for enzymes act on, and the cycle doesn't "get stuck" just because things don't add up in a single turn. The "regenerating" steps between PGAL and RuBP produce 3 molecules of RuBP from 5 molecules of PGAL (15 carbons total). Carboxylating these 3 RuBP molecules adds 3 carbons, so that one PGAL molecule can leave the cycle.

The reason for this odd stoichiometry is that the cycle needs to turn 3-carbon sugars (PGAL) into 5-carbon sugars (RuBP), which is rather complicated. Several enzymes work together in a complicated series of reactions to achieve this. A good resource for learning about the details is the MetaCyc database, where you can explore all the molecular details of the pathway.

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