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Dror Hilman's user avatar
Dror Hilman's user avatar
Dror Hilman's user avatar
Dror Hilman
  • Member for 9 years, 1 month
  • Last seen more than 6 years ago
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How are the dominance and additive effects reflected in the mean and variance of the offsprings of two individuals with known phenotype?
Let say I have large phenotypic data, spanning many parents, children and environments. I estimated the broad sense Heritability from siblings ANOVA, the narrow sense heritability from parent-offs. regression (~σ2A). and the environment effect from comparing individuals across environments. So now, given a random parent values, The predicted children mean will be the parent mean + some X value, associated with the dominance effect, and variance coming from the enviro. effect. how to calculate this "X" factor ? This what puzzles me. - what will be the mean and var. of the population?
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Stem cell research and female egg synthesis
I see, so what you are actually asking is about reprogramming cells to become eggs?
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How are the dominance and additive effects reflected in the mean and variance of the offsprings of two individuals with known phenotype?
I would like to simulate a population in which I know the real heritability, dominance effects and environment effect, estimated from sibling ANOVA, parent-offspring regression and comparing different environments. Although I can understand the role of these effects on a large population, I am not sure how to apply this to the predicted parameters of each individual offspring of two individual parents. What will be the right formula to estimate the phenotype of each offspring in the simulation?
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How are the dominance and additive effects reflected in the mean and variance of the offsprings of two individuals with known phenotype?
I see, but how the dominance effect changes the mean? and what will be the variance of the offspring population - is it just the environmental related variance?
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How to estimate heritability from breeding data
Thank you very much, it was very helpful. I went on trying with the REML/MCMC methods, and will check how it goes.
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