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I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers.

Due to the end-replication problem,5,6 the ends of linear chromosomes shorten with each round of DNA replication.7 In human somatic cells, the progressive telomere shortening that occurs with continued proliferation eventually results in the triggering of a replicative checkpoint. Telomere shortening and the structural changes that it presumably causes, leads to a DNA-damage checkpoint response at the telomere and induction of a permanent p53- and Rb-dependent growth arrest (i.e., replicative senescence).8-10 Because this limits the proliferative capacity of somatic cells, including those that have accumulated oncogenic mutations, telomere shortening and replicative senescence are a potent tumor suppressor mechanism.

The paragraph states a shorter telomere is a potential suppressor to cancers. Why is that? Why exactly a somatic cell proliferate slower with a shorter telomere DNA sequence?

Conversely, why a longer minority leads to human cancers?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers.

Due to the end-replication problem,5,6 the ends of linear chromosomes shorten with each round of DNA replication.7 In human somatic cells, the progressive telomere shortening that occurs with continued proliferation eventually results in the triggering of a replicative checkpoint. Telomere shortening and the structural changes that it presumably causes, leads to a DNA-damage checkpoint response at the telomere and induction of a permanent p53- and Rb-dependent growth arrest (i.e., replicative senescence).8-10 Because this limits the proliferative capacity of somatic cells, including those that have accumulated oncogenic mutations, telomere shortening and replicative senescence are a potent tumor suppressor mechanism.

The paragraph states a shorter telomere is a potential suppressor to cancers. Why is that? Why exactly a somatic cell proliferate slower with a shorter telomere DNA sequence?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers.

Due to the end-replication problem,5,6 the ends of linear chromosomes shorten with each round of DNA replication.7 In human somatic cells, the progressive telomere shortening that occurs with continued proliferation eventually results in the triggering of a replicative checkpoint. Telomere shortening and the structural changes that it presumably causes, leads to a DNA-damage checkpoint response at the telomere and induction of a permanent p53- and Rb-dependent growth arrest (i.e., replicative senescence).8-10 Because this limits the proliferative capacity of somatic cells, including those that have accumulated oncogenic mutations, telomere shortening and replicative senescence are a potent tumor suppressor mechanism.

The paragraph states a shorter telomere is a potential suppressor to cancers. Why is that? Why exactly a somatic cell proliferate slower with a shorter telomere DNA sequence?

Conversely, why a longer minority leads to human cancers?

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SmallChess
SmallChess
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Why telomere shortening slowslowing down cancer?

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SmallChess
SmallChess
  • 1k
  • 13
  • 24

Why telomere shortening slow down cancer?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers.

Due to the end-replication problem,5,6 the ends of linear chromosomes shorten with each round of DNA replication.7 In human somatic cells, the progressive telomere shortening that occurs with continued proliferation eventually results in the triggering of a replicative checkpoint. Telomere shortening and the structural changes that it presumably causes, leads to a DNA-damage checkpoint response at the telomere and induction of a permanent p53- and Rb-dependent growth arrest (i.e., replicative senescence).8-10 Because this limits the proliferative capacity of somatic cells, including those that have accumulated oncogenic mutations, telomere shortening and replicative senescence are a potent tumor suppressor mechanism.

The paragraph states a shorter telomere is a potential suppressor to cancers. Why is that? Why exactly a somatic cell proliferate slower with a shorter telomere DNA sequence?