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Post Reopened by AliceD♦
Shifted to focus to one question.
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Kitlo
Kitlo
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A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population has at three (3) RFLP (this is a type of DNA marker; they are not SNPs so have much larger sizes) alleles in this region. The sizes of the RFLP alleles are 7, 10 or 13 kb in length. Shown here are two small pedigrees of families in which affected individuals are shaded in black. The size of the RFLP alleles each individual carries is shown below the pedigree. enter image description here

enter image description here

a. Which RFLP allele is associated with the disease mutation in the father shown in the pedigree on the left? (see all genotypes below)

b. Which restriction fragment is associated with the disease mutation in the mother shown in the pedigree on the right?

c.Question: If the male child from the left pedigree marries the female child from the right pedigree, what is the probability their child will be diseased?

d. What is the probability their child will be a carrier?

I put down the answers a. RFLP 10kb and 13kb b. RFLP 7kb and 10kb c. The offspring has a 0% chance to inherit the disease since they would inherit the 7kb RFLP from their parents. d. There isn't enough information to tell since the parents genotypes are unknown. I'm not so sure answer d is correct though. I said that there isn't enough information to tell since the parents genotypes are unknown.

A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population has at three (3) RFLP (this is a type of DNA marker; they are not SNPs so have much larger sizes) alleles in this region. The sizes of the RFLP alleles are 7, 10 or 13 kb in length. Shown here are two small pedigrees of families in which affected individuals are shaded in black. The size of the RFLP alleles each individual carries is shown below the pedigree. enter image description here

enter image description here

a. Which RFLP allele is associated with the disease mutation in the father shown in the pedigree on the left? (see all genotypes below)

b. Which restriction fragment is associated with the disease mutation in the mother shown in the pedigree on the right?

c. If the male child from the left pedigree marries the female child from the right pedigree, what is the probability their child will be diseased?

d. What is the probability their child will be a carrier?

I put down the answers a. RFLP 10kb and 13kb b. RFLP 7kb and 10kb c. The offspring has a 0% chance to inherit the disease since they would inherit the 7kb RFLP from their parents. d. There isn't enough information to tell since the parents genotypes are unknown. I'm not so sure answer d is correct though.

A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population has at three (3) RFLP (this is a type of DNA marker; they are not SNPs so have much larger sizes) alleles in this region. The sizes of the RFLP alleles are 7, 10 or 13 kb in length. Shown here are two small pedigrees of families in which affected individuals are shaded in black. The size of the RFLP alleles each individual carries is shown below the pedigree. enter image description here

enter image description here

Question: If the male child from the left pedigree marries the female child from the right pedigree, What is the probability their child will be a carrier?

I said that there isn't enough information to tell since the parents genotypes are unknown.

Post Closed as "Needs more focus" by theforestecologist♦
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Kitlo
Kitlo
  • 19
  • 3

RFLP Pedigree question

A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population has at three (3) RFLP (this is a type of DNA marker; they are not SNPs so have much larger sizes) alleles in this region. The sizes of the RFLP alleles are 7, 10 or 13 kb in length. Shown here are two small pedigrees of families in which affected individuals are shaded in black. The size of the RFLP alleles each individual carries is shown below the pedigree. enter image description here

enter image description here

a. Which RFLP allele is associated with the disease mutation in the father shown in the pedigree on the left? (see all genotypes below)

b. Which restriction fragment is associated with the disease mutation in the mother shown in the pedigree on the right?

c. If the male child from the left pedigree marries the female child from the right pedigree, what is the probability their child will be diseased?

d. What is the probability their child will be a carrier?

I put down the answers a. RFLP 10kb and 13kb b. RFLP 7kb and 10kb c. The offspring has a 0% chance to inherit the disease since they would inherit the 7kb RFLP from their parents. d. There isn't enough information to tell since the parents genotypes are unknown. I'm not so sure answer d is correct though.