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tumour budding, lymphocytic infiltration and resection margins are established factors that influence the outcome of colorectal cancer (1)

In this context what does "tumour budding" mean?

Reference

(1) A. Bolocan, D. Ion, D.N. Ciocan, D.N Paduraru. Chirurgia (2012) 107:555-563. Introduction/0

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Tumor ‘budding’ is loosely defined as the presence of individual cells and small clusters of tumor cells at the invasive front of carcinomas. A study of the measure of budding can give an insight into how fast the disease might propogate.

Reference

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