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Questions pertaining to organized collections of biological data.

1 vote
1 answer
59 views

Why does uniprot sometimes not label single-pass transmembrane proteins as "anchors"?

Currently, section 3a) of unitprot TRANSMEM reference page divides single-pass transmembrane proteins into 4 types: I, II, III, IV. I is not explicitly labelled as an "anchor" whereas the others are. …
James's user avatar
  • 11.3k
2 votes
0 answers
50 views

Do GPCRs have 7TMHs?

I've screened a non-redundant set of GPCRs acquired from UniProt. I found a handful of examples of record IDs that contain more than the 7 TMHs. For example Q89609 and P20905, both of which have been …
James's user avatar
  • 11.3k
2 votes
1 answer
74 views

What does uniprot consider "unambiguous" evidence for the subcellular domain of a protein?

Uniprot has annotation for subcellular location of protein domains. This topological domain information of proteins is under the TOPO_DOM flag. In most cases the subcellular location is assigned by r …
James's user avatar
  • 11.3k
14 votes
2 answers
1k views

Why and how does uniprot list around 150,000 proteins in the human genome?

Is this something to do with splice isoforms, like those from SpliceProt, or another splice isoform database or tool? …
James's user avatar
  • 11.3k