If an European male (i.e. white) is diagnosed with schizophrenia, but an European female (also white) 2-3 years younger than the male is healthy, what is the probability that their first child will:
a) be diagnosed with schizophrenia later in life?
b) have some other mental condition?
Haven't directly answered this
I found a recent literature review that is relevant to this:
"Gene-Environment Interactions in Schizophrenia: A Literature Review"
by Marah H. Wahbeh and Dimitrios Avramopoulos *Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Academic Editor: Sarah Tosato Genes 2021, 12(12), 1850; https://doi.org/10.3390/genes12121850 (registering DOI)
This article notes that the chance of schizophrenia is more likely to arise if one of a group of conditions is present.
Conditions such as prenatal maternal exposure to some infections, childhood adversity, and cannabis use.
As far as increased chance of other disorders, the below article only uses the measure of first or second degree relatives - not chance of heritability from a parent only. This study uses the entire population of Taiwan.
"Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families"
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng ...
Schizophrenia Bulletin, Volume 43, Issue 5, September 2017, Pages 1070–1078, https://doi.org/10.1093/schbul/sbw159
"The RR (95% CI) in individuals with a first-degree relative with schizophrenia was 3.49 (3.34–3.64) for mood disorders and 3.91 (3.35–4.57) for delusional disorders."
(RR is relative risk.)
