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For humans it has been reported that there are three vasopressin receptors (AVPR1a) and four dopamine receptors (DRD2). (Source: UNIPROT)

Question: Does every human contain all three variants of AVPR1a? Or is it the case that some individuals contain fewer than the three variants found in the total population?

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    $\begingroup$ do you mean variation in one gene or presence and absence of multiple paralogs/copies of these genes? I don't see where you are getting this info in uniprot, directly linking/screenshotting would be helpful. $\endgroup$
    – Maximilian Press
    Commented Sep 8, 2022 at 20:27

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Short answer: my database search yielded different results: Three receptors were identified with different names: AVPR1A, AVPR1B, AVPR2.

I have actually never heard of a distinct human population completely lacking one gene (I might be mistaken). Usually, only single nucleotide polymorphisms vary between populations. I also do not think that this matters, unless your project addresses specifically that question.

I find three paralogues of the vasopressin receptor (homologous copies of a "similar" receptor found on different chromosomes): AVPR1A, AVPR1B, AVPR2 (might have missed one though)

If these receptors pop up in a search in a human database, their mRNA (cDNA) was sequenced at some point from human tissue and annotated to the genome.

Protein Atlas shows two splice variants ("number of transcripts") of AVPR1A.

NCBI shows one splice variant of AVPR1a from three different databases (MANE, NCBI, Ensembl). (please see this tutorial to use the NCBI-genome viewer)

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