I was wondering whether anyone has looked at what are the expression changes in yeast when the microtubule or the microfilament polymerization is inhibited? Have there been whole-genome studies?


Browsing around GEO, I see 13 experiments focusing on microtubule disruption in yeast.

This CHIP-CHP experiment actually uses nocodazole.

This is a microarray experiment with benomyl treatment.

The rest focus on specific mutants that try to perturb the microtubules in specific ways.

What's more if you broaden the search there is an extensive body of work including human cell lines work as well...

  • $\begingroup$ Thanks for the answer. Could you summarize what was discovered? Which genes were downregulated/upregulated/unchanged? Thanks. $\endgroup$ – Gergana Vandova Feb 25 '14 at 18:49
  • $\begingroup$ GEO doesn't store results. I'd have to go and redo the analyses myself.... $\endgroup$ – shigeta Feb 25 '14 at 18:52

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