I am writing a paper for non coding SNPs on patients with metastatic breast cancer. Having used a specific gene panel (NGS) of approximately 60 genes, I'm currently running out of ideas on what to write in the discussion section.
I am looking for suggestions based on somewhat efficient methods like a bioinformatics approach or specific textbooks revolving around RNA biology/biochemistry, in order to predict the outcome of non-coding SNP variants.
The majority of the variants are intronic (~2300/3300), so I will mostly focus on splicing.
There are two commonly repeated SNPs in 3'-UTRs in over half of the patients, involving KRAS and CDKN2A.