I'm reading this paper, and I'm already lost in terms of what they mean by GPCR signaling is spatially encoded.
The trafficking of G protein coupled‐receptors (GPCRs) is one of the most exciting areas in cell biology because of recent advances demonstrating that GPCR signaling is spatially encoded.
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Some GPCRs appear to regulate their own endocytic rate through modulation of clathrin‐coated pit (CCP) maturation.12-14 This regulation, which can differ between ligands acting at the same GPCR, is an additional method by which GPCR signaling can be spatially encoded.
How can signaling be spatially encoded?
