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What are the major differences between them, apart from one being in humans and other in Drosophilla?

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In Drosophila, Toll receptors are used during embryonic development as well as innate immunity. See The Drosophila Toll Signaling Pathway by Valance, et. al.

Toll-like Receptors are pattern recognition receptors found in organisms other than Drosophila that recognize common motifs found on pathogens.

Toll receptors were first discovered in Drosophila and orthologous receptors were then found in many other organisms, not only Human. Both will transduce signaling and will lead to transcription of genes.

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