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Hi I was just wondering whether there would be any difference to the structure of the polypeptide chain, or any changes to a proteins characteristics, if it has more amide groups with a cis or trans configuration.

Apparently the trans configuration is more stable, so more amino acids with a trans configuration can be found within a polypeptide chain. Does this pose any significant characteristic to a protein, and if so what is this characteristic?

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Apparently the trans configuration is more stable, so more amino acids with a trans configuration can be found within a polypeptide chain. Does this pose any significant characteristic to a protein, and if so what is this characteristic?

As you said, the trans- form is energetically more favourable. However, in proline the cis- form is energetically similar to the trans- form. The cis- structure introduces a kink or bend in the peptide chain which is seen in case of proline (see this section of wikipedia page on proline).

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