Growth hormone and insulin like growth factors are diabetogenic, so I assume that people with high growth hormone (say due to pituitary tumor) may be at high risk for diabetes. Has any correlation been established between these two? I know that diabetes is a multifactorial disorder and so only a correlation may be established.

  • $\begingroup$ Which type of diabetes mellitus are you interested in? Or both? $\endgroup$
    – user560
    Oct 22, 2013 at 23:06
  • $\begingroup$ @leonardo I think this should not affect diabetes type 1 as dt1 is a mostly autoimmune disorder. So if some papers are available on this, I think, they would mostly be on type 2. $\endgroup$
    – biogirl
    Oct 23, 2013 at 9:08

1 Answer 1



That GH has an effect on glycaemic control is most evident from the abnormal glucose tolerance seen in acromegalics...

acromegaly is defined as abnormal growth of the hands, feet, and face, caused by overproduction of growth hormone by the pituitary gland.

Such an effect has been known for decades, which makes sense given how interrelated the axes are. Although I think the best evidence is the fact that the side effects of growth hormone therapy says that Some patients have developed diabetes mellitus...


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