3
$\begingroup$

I'm trying to learn more about polarized epithelial cells of the gut. I am familiar with classic brush border transporters localized to the apical memebrane to facilitate nutrient absorption. I am wondering though, where are ion channels located? I would guess basolaterally since they would be exposed to the extracellular space. I would appreciate a primary reference showing the location of voltage-gated channels in particular as I could not find them myself.

$\endgroup$
3
$\begingroup$

Well, that's a first for me. I wouldn't have guessed gut cells would have voltage-gated channels. This article describes voltage-gated sodium channels on both the luminal and basolateral membranes:

Barshack, I., Levite, M., Lang, A., Fudim, E., Picard, O., Ben Horin, S., & Chowers, Y. (2008). Functional voltage-gated sodium channels are expressed in human intestinal epithelial cells. Digestion, 77(2), 108-117. http://www.ncbi.nlm.nih.gov/pubmed/18391489

$\endgroup$
  • 1
    $\begingroup$ Thanks for the suggested article. I'm not able to get it through my institution, do you have a copy, or can you quote the relevant results? $\endgroup$ – user560 Apr 28 '14 at 21:55
  • 1
    $\begingroup$ Check your email, Leonardo. $\endgroup$ – Adrienne Apr 29 '14 at 15:44

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy