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  1. Why can't mutated RAS get inactivated by GTPase?
  2. Why don't we have any inhibitors for RAS-GTP binding?
  3. Why is RAS undruggable?
  4. How can mutated RAS be inactivated?

I had been researching on the topic and had a lot of doubts in the regard. Please provide me direction, as to where can I find answers to the questions and continue the research "how can mutated RAS be inactivated?"

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    $\begingroup$ This is not one, but four questions and all of them are quite complex - actually these are the key question to treating a lot of cancers. Can you please narrow it down? $\endgroup$
    – Chris ♦
    Commented Aug 27, 2016 at 8:06
  • $\begingroup$ Do you have a reference for question 3? Why do you think RAS is undruggable? $\endgroup$
    – Ashafix
    Commented Aug 27, 2016 at 11:43
  • $\begingroup$ www.nature.com/nrd/journal/v13/n11/full/nrd4389.html $\endgroup$
    – Parth Raghav
    Commented Aug 27, 2016 at 11:51

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