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Tagged with binding-sites theoretical-biology
2 questions
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How much does the distance between a transcription factor binding site and a promoter influence transcription?
Assume we have a synthetic construct with a minimal (inducible) promoter that requires activation for significant transcription to occur. Realistically, how important is the distance between an ...
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3
votes
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Is there a way to determine corresponding differential equations from fitted Hill equation parameters
I am currently doing some work with GCaMP, a genetically encoded calcium indicator. According to the literature the Hill equation parameters for GCaMP6m is $K_d=167\pm3\, \text{nM}$ and $n=2.96\pm0.04$...
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