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Results tagged with rna
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user 389
RNA, or ribonucleic acid, is a biological macromolecule made of nucleotides used in cells to convey genetic information to protein. RNA also plays a role in catalyzing certain biological reactions as well as carrying genetic material in some viruses.
2
votes
Finding RNA Loops
I also suggest checking out https://www.mendeley.com/groups/545791/rna-structure/. … But for now, I think Revolutions in RNA Secondary Structure Prediction by David Mathews who developed the Turner rules and Mfold is a good start. …
- 7,877
14
votes
Accepted
Why does RNA adopt an A-form helix?
RNA does not have this luxury. The steric clash of the 2-OH with the 3'-OH makes the B-form to be very unfavorable thus constraining the RNA to adopt the A-form. … Incidentally this steric limitation is also why RNA structures are more stable (see https://biology.stackexchange.com/a/769/389) …
- 7,877
5
votes
What implications has the missing 2'-OH on the capability of DNA to form 3D structures?
As mentioned by Aleksandra, RNA will adopt only the C3'-endo conformation whereas DNA adopts both the C2'-endo and C3'-endo. Effectively, this makes the DNA strand more flexible not RNA. … DNA/RNA helix formation is dominantly enthalpically driven. When a helix forms, RNA will only adopt an A-form Helix where as DNA will adopt both a A-form and B-form. …
- 7,877
10
votes
Can methylation from DNA get copied to RNA during transcription?
I don't believe anything should change in the majority of DNA->RNA transcription. DNA methylation typically occurs on the non-watson crick side of Cytosine so it shouldn't affect the base-pairing. … Does the 5mCytosine affect the fidelity of RNA polymerase? I honestly don't know but it would be worth examining. …
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