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Coronaviruses are a family of viruses that cause disease in humans and animals. They are named for the crown-like spike proteins on their surface.

4 votes
Accepted

What is the motivation behind the CCA -> CCU modification between SARS-CoV-2 and the mRNA va...

The article mentioned says: Why would you do that? As noted above, our immune system takes a very dim view of ‘exogenous’ RNA, RNA code coming from outside the cell. To evade detection, the ‘U’ in th …
Polypipe Wrangler's user avatar
1 vote

What are the difficulties/challenges against developing a coronavirus vaccine?

Immunology is very complex, with so many interactions that prediction is difficult. For example, some vaccine candidates will probably be designed to provoke an immune response against the proteins o …
Polypipe Wrangler's user avatar
1 vote
Accepted

Do we know if dogs are asymptomatic transmiters of sars-cov-2?

"Coronavirus can infect cats - dogs, not so much." https://www.nature.com/articles/d41586-020-00984-8 found by searching "dog" on LitCovid at https://www.ncbi.nlm.nih.gov/research/coronavirus/ …
Polypipe Wrangler's user avatar
1 vote

What are the implications of tigers being susceptible to SARS-CoV-2?

A single strain of virus (such as rabies) can infect multiple species of hosts. The big question is whether domestic cats also get infected? If they do, two main problems. There would be a reservoir …
Polypipe Wrangler's user avatar
1 vote

Reasons why this protein is not suitable as an immunogen?

The article implies E proteins are quite different between the previous known strains - so a vaccine targeted against E protein may only affect a limited range of strains. But when I do a BLAST searc …
Polypipe Wrangler's user avatar
-1 votes
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Can swarming locusts act as a vector for any human pathogens?

I have not heard of locusts being a vector for any pathogen. For immunocompromised people, they can on rare occasions be infected by bacteria carried in the guts of insects. For desert locusts, their …
Polypipe Wrangler's user avatar